Distinct mutations at the same positions of STAT3 cause either loss or gain of function

J Allergy Clin Immunol. 2016 Oct;138(4):1222-1224.e2. doi: 10.1016/j.jaci.2016.05.007. Epub 2016 May 24.
No abstract available

Publication types

  • Letter

MeSH terms

  • Amino Acid Substitution
  • Animals
  • COS Cells
  • Cell Line
  • Chlorocebus aethiops
  • Gain of Function Mutation*
  • Humans
  • Job Syndrome / genetics
  • Loss of Function Mutation*
  • Lymphoproliferative Disorders / genetics
  • Models, Molecular
  • Mutant Proteins / chemistry
  • Mutant Proteins / genetics
  • Recombinant Proteins / chemistry
  • Recombinant Proteins / genetics
  • STAT3 Transcription Factor / chemistry
  • STAT3 Transcription Factor / genetics*
  • STAT3 Transcription Factor / immunology
  • Static Electricity
  • src Homology Domains / genetics

Substances

  • Mutant Proteins
  • Recombinant Proteins
  • STAT3 Transcription Factor
  • STAT3 protein, human