Negative results in phase III trials of complex interventions: cause for concern or just good science?

Br J Psychiatry. 2016 Jul;209(1):6-8. doi: 10.1192/bjp.bp.115.179747.

Abstract

Not all interventions that show promise in exploratory trials will be supported in phase III studies. But the high failure rate in recent trials of complex mental health interventions is a concern. Proper consideration of trial processes and greater use of adaptive trial designs could ensure better use of available resources.

Publication types

  • Editorial
  • Comment

MeSH terms

  • Clinical Trials, Phase III as Topic / standards*
  • Humans