International AIDS Society global scientific strategy: towards an HIV cure 2016

Steven G Deeks; Sharon R Lewin; Anna Laura Ross; Jintanat Ananworanich; Monsef Benkirane; Paula Cannon; Nicolas Chomont; Daniel Douek; Jeffrey D Lifson; Ying-Ru Lo; Daniel Kuritzkes; David Margolis; John Mellors; Deborah Persaud; Joseph D Tucker; Françoise Barre-Sinoussi; International AIDS Society Towards a Cure Working Group; Galit Alter; Judith Auerbach; Brigitte Autran; Dan H Barouch; Georg Behrens; Marina Cavazzana; Zhiwei Chen; Éric A Cohen; Giulio Maria Corbelli; Serge Eholié; Nir Eyal; Sarah Fidler; Laurindo Garcia; Cynthia Grossman; Gail Henderson; Timothy J Henrich; Richard Jefferys; Hans-Peter Kiem; Joseph McCune; Keymanthri Moodley; Peter A Newman; Monique Nijhuis; Moses Supercharger Nsubuga; Melanie Ott; Sarah Palmer; Douglas Richman; Asier Saez-Cirion; Matthew Sharp; Janet Siliciano; Guido Silvestri; Jerome Singh; Bruno Spire; Jeffrey Taylor; Martin Tolstrup; Susana Valente; Jan van Lunzen; Rochelle Walensky; Ira Wilson; Jerome Zack

doi:10.1038/nm.4108

International AIDS Society global scientific strategy: towards an HIV cure 2016

Nat Med. 2016 Aug;22(8):839-50. doi: 10.1038/nm.4108. Epub 2016 Jul 11.

Authors

Steven G Deeks¹, Sharon R Lewin^{2

3}, Anna Laura Ross⁴, Jintanat Ananworanich^{5

6}, Monsef Benkirane⁷, Paula Cannon⁸, Nicolas Chomont⁹, Daniel Douek¹⁰, Jeffrey D Lifson¹¹, Ying-Ru Lo¹², Daniel Kuritzkes¹³, David Margolis¹⁴, John Mellors¹⁵, Deborah Persaud¹⁶, Joseph D Tucker¹⁷, Françoise Barre-Sinoussi¹⁸; International AIDS Society Towards a Cure Working Group; Galit Alter¹⁹, Judith Auerbach¹, Brigitte Autran^{20

21

22}, Dan H Barouch^{23

19}, Georg Behrens²⁴, Marina Cavazzana²⁵, Zhiwei Chen²⁶, Éric A Cohen²⁷, Giulio Maria Corbelli²⁸, Serge Eholié²⁹, Nir Eyal³⁰, Sarah Fidler³¹, Laurindo Garcia³², Cynthia Grossman³³, Gail Henderson¹⁴, Timothy J Henrich^{1

13}, Richard Jefferys³⁴, Hans-Peter Kiem³⁵, Joseph McCune¹, Keymanthri Moodley³⁶, Peter A Newman³⁷, Monique Nijhuis³⁸, Moses Supercharger Nsubuga³⁹, Melanie Ott⁴⁰, Sarah Palmer⁴¹, Douglas Richman⁴², Asier Saez-Cirion¹⁸, Matthew Sharp⁴³, Janet Siliciano⁴⁴, Guido Silvestri⁴⁵, Jerome Singh⁴⁶, Bruno Spire⁴⁷, Jeffrey Taylor⁴⁸, Martin Tolstrup⁴⁹, Susana Valente⁵⁰, Jan van Lunzen⁵¹, Rochelle Walensky⁵², Ira Wilson⁵³, Jerome Zack⁵⁴

Affiliations

¹ Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
² The Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Melbourne, Australia.
³ Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia.
⁴ International and Scientific Relations Office, ANRS, Paris, France.
⁵ US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
⁶ Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
⁷ Molecular Virology Lab, Institute of Human Genetics, CNRS UPR 1142, Université de Montpellier, Montpellier, France.
⁸ Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
⁹ CRCHUM and Department of Microbiology, Infectiology, and Immunology, Université de Montréal, Faculty of Medicine, Montréal, Quebec, Canada.
¹⁰ Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
¹¹ AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory, Frederick, Maryland, USA.
¹² World Health Organization Regional Office for the Western Pacific, Manila, Philippines.
¹³ Brigham &Women's Hospital, Boston, Massachusetts, USA.
¹⁴ University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.
¹⁵ Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
¹⁶ Johns Hopkins University School of Medicine &Bloomberg School of Public Health, Baltimore, Maryland, USA.
¹⁷ University of North Carolina-Project China, Guangzhou, China.
¹⁸ Institut Pasteur, Paris, France.
¹⁹ Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA.
²⁰ Sorbonne Universités, UPMC Univ Paris 06, CIMI-Paris, France.
²¹ Inserm U1135, CIMI-Paris, Paris, France.
²² AP-HP, Hôpital Pitié-Salpêtrière, Département d'Immunologie, Paris, France.
²³ Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
²⁴ Clinic for Immunology and Rhematology, Hannover Medical School, Hanover, Germany.
²⁵ Centre d'Investigation Clinique en biothérapie, Hôpital Necker-Enfants Malades, Paris, France.
²⁶ AIDS Institute, The University of Hong Kong, Pok Fu Lam, Hong Kong.
²⁷ Institut de Recherches Cliniques de Montréal, Université de Montréal, Montréal, Quebec, Canada.
²⁸ European AIDS Treatment Group, Italy.
²⁹ Programme PAC-CI, Centre Hospitalier Universitaire de Treichville, Abidjan, Côte d'Ivoire.
³⁰ Harvard T. H. Chan School of Public Health, Department of Global Health and Population, Boston, Massachusetts, USA.
³¹ Department of Medicine, Imperial College London, London, United Kingdom.
³² The B-Change Group, Manila, Philippines.
³³ National Institute of Mental Health, NIH, Bethesda, Maryland, USA.
³⁴ Treatment Action Group, New York, New York, USA.
³⁵ Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
³⁶ Centre for Medical Ethics and Law, Department of Medicine, Stellenbosch University, Western Cape, South Africa.
³⁷ Factor-Inwentash Faculty of Social Work, University of Toronto, Toronto, Ontario, Canada.
³⁸ Department of Medical Microbiology, Virology, University Medical Center Utrecht, Utrecht, Netherlands.
³⁹ Joint Clinical Research Centre, Kampala, Uganda.
⁴⁰ Gladstone Institutes, University of California, San Francisco, San Francisco, California, USA.
⁴¹ Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, Australia.
⁴² Virginia San Diego Healthcare System and University of California, San Diego, San Diego, California, USA.
⁴³ Independent HIV Education and Advocacy Consultant, San Francisco, California, USA.
⁴⁴ Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁴⁵ Yerkes National Primate Research Centre, Emory University, Atlanta, Georgia, USA.
⁴⁶ Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
⁴⁷ INSERM UMR_S912, Marseille, France.
⁴⁸ CARE Collaboratory Community Advisory Board, Palm Springs, California, USA.
⁴⁹ Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.
⁵⁰ Department of Immunology and Microbial Sciences, The Scripps Research Institute, Jupiter, Florida, USA.
⁵¹ ViiV Healthcare, London, United Kingdom.
⁵² Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
⁵³ Department of Health Services, Policy &Practice, Brown University School of Public Health, Providence, Rhode Island, USA.
⁵⁴ David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

PMID: 27400264
PMCID: PMC5322797
DOI: 10.1038/nm.4108

Abstract

Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a global population of more than 35 million people living with HIV, there is intense interest in developing a cure for HIV infection. The International AIDS Society convened a group of international experts to develop a scientific strategy for research towards an HIV cure. This Perspective summarizes the group's strategy.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Acquired Immunodeficiency Syndrome / therapy*
Goals*
HIV Infections / therapy*
Humans
International Cooperation
Organizational Objectives
Research*
Societies, Medical

Abstract

Publication types

MeSH terms

Grants and funding