Size matters: Survival benefit conferred by intratumoral T cells is dependent on surgical outcome, treatment sequence and T cell differentiation

M C A Wouters; F L Komdeur; M de Bruyn; H W Nijman

doi:10.1080/2162402X.2015.1122863

Size matters: Survival benefit conferred by intratumoral T cells is dependent on surgical outcome, treatment sequence and T cell differentiation

Oncoimmunology. 2016 Jan 4;5(5):e1122863. doi: 10.1080/2162402X.2015.1122863. eCollection 2016 May.

Authors

M C A Wouters¹, F L Komdeur², M de Bruyn², H W Nijman²

Affiliations

¹ Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
² Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen , Groningen, The Netherlands.

Abstract

Outcome of cytoreductive surgery, treatment sequence and the differentiation status of T cells are key factors to take into account when studying the prognostic value of tumor-infiltrating lymphocytes (TIL) in high grade serous ovarian cancer.

Keywords: CD27; high-grade serous epithelial ovarian cancer; neo-adjuvant chemotherapy; surgical cytoreduction; tumor-infiltrating lymphocytes.