Eosinophilic esophagitis

Trop Gastroenterol. 2015 Jul-Sep;36(3):156-67. doi: 10.7869/tg.277.

Abstract

Eosinophilic esophagitis (EoE) is a clinico-pathological entity characterised by symptoms of esophageal dysfunction and eosinophilia on esophageal mucosal biopsies in the absence of other causes of esophageal eosinophilia. It is a chronic inflammatory condition of esophagus often characterized by refractory reflux symptoms in children and dysphagia in adults. It occurs as a result of Th2 inflammatory response to environmental triggers (food antigens) in genetically predisposed individuals. The diagnostic criteria include symptoms of esophageal dysfunction, esophageal eosinophilia (> 15/hpf), and a PPI trial (persistent eosinophilia after 8 weeks of PPI). Mainstay of treatment at present is topical steroids and dietary therapy. Maintenance treatment should be considered to prevent long term complications.

Publication types

  • Review

MeSH terms

  • Diagnosis, Differential
  • Eosinophilic Esophagitis / diagnosis*
  • Eosinophilic Esophagitis / epidemiology
  • Eosinophilic Esophagitis / therapy*
  • Humans