Consensus definitions for pediatric MS and other demyelinating disorders in childhood

Marc Tardieu; Brenda Banwell; Jerry S Wolinsky; Daniela Pohl; Lauren B Krupp

doi:10.1212/WNL.0000000000002877

Consensus definitions for pediatric MS and other demyelinating disorders in childhood

Neurology. 2016 Aug 30;87(9 Suppl 2):S8-S11. doi: 10.1212/WNL.0000000000002877.

Authors

Marc Tardieu¹, Brenda Banwell², Jerry S Wolinsky², Daniela Pohl², Lauren B Krupp²

Affiliations

¹ From the National Reference Center for Inflammatory Diseases of the Brain (M.T.), Hôpitaux Universitaires Paris-Sud, University Paris-Sud, France; Perelman School of Medicine (B.B.), The Children's Hospital of Philadelphia, University of Pennsylvania; University of Texas Health Science Center at Houston (J.W.); Department of Neurology (D.P.), Children's Hospital of Eastern Ontario, University of Ottawa, Canada; and Lourie Center for Pediatric MS (L.B.K.), Stony Brook Children's, NY. marc.tardieu@bct.aphp.fr.
² From the National Reference Center for Inflammatory Diseases of the Brain (M.T.), Hôpitaux Universitaires Paris-Sud, University Paris-Sud, France; Perelman School of Medicine (B.B.), The Children's Hospital of Philadelphia, University of Pennsylvania; University of Texas Health Science Center at Houston (J.W.); Department of Neurology (D.P.), Children's Hospital of Eastern Ontario, University of Ottawa, Canada; and Lourie Center for Pediatric MS (L.B.K.), Stony Brook Children's, NY.

PMID: 27572866
DOI: 10.1212/WNL.0000000000002877

Abstract

In light of the published 2012 International Pediatric Multiple Sclerosis Group definitions for pediatric multiple sclerosis (MS) and related disorders and given that pediatric-onset MS is now formally included in the 2010 McDonald criteria for MS, we sought to review these criteria and summarize their application in children with acquired CNS demyelination. In addition, proposals are made for definitions of no evidence of disease activity and inadequate treatment response that are important because of new therapeutic options and trials.

Publication types

Review

MeSH terms

Consensus*
Demyelinating Diseases / diagnosis*
Humans
Multiple Sclerosis / diagnosis*
Pediatrics / standards*