Variation in Hospital Risk-Adjusted Mortality Rates Following Transcatheter Aortic Valve Replacement in the United States: A Report From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry

Sean M O'Brien; David J Cohen; John S Rumsfeld; J Matthew Brennan; David M Shahian; David Dai; David R Holmes; Rosemarie B Hakim; Vinod H Thourani; Eric D Peterson; Fred H Edwards; STS/ACC TVT Registry

doi:10.1161/CIRCOUTCOMES.116.002756

Variation in Hospital Risk-Adjusted Mortality Rates Following Transcatheter Aortic Valve Replacement in the United States: A Report From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry

Circ Cardiovasc Qual Outcomes. 2016 Sep;9(5):560-5. doi: 10.1161/CIRCOUTCOMES.116.002756. Epub 2016 Sep 13.

Affiliations

¹ From the Duke University Medical Center, Durham, NC (S.M.O., J.M.B., D.D., E.D.P.); Saint Luke's Mid America Heart Institute, Kansas City, MO (D.J.C.); Denver VA Medical Center, CO (J.S.R.); Massachusetts General Hospital, Boston (D.M.S.); Mayo Clinic, Rochester, MN (D.R.H.); Centers for Medicare & Medicaid Services, Baltimore, MD (R.B.H.); Emory University School of Medicine, Atlanta, GA (V.H.T.); and University of Florida, Jacksonville (F.H.E.). sean.m.obrien@duke.edu.
² From the Duke University Medical Center, Durham, NC (S.M.O., J.M.B., D.D., E.D.P.); Saint Luke's Mid America Heart Institute, Kansas City, MO (D.J.C.); Denver VA Medical Center, CO (J.S.R.); Massachusetts General Hospital, Boston (D.M.S.); Mayo Clinic, Rochester, MN (D.R.H.); Centers for Medicare & Medicaid Services, Baltimore, MD (R.B.H.); Emory University School of Medicine, Atlanta, GA (V.H.T.); and University of Florida, Jacksonville (F.H.E.).

PMID: 27625404
DOI: 10.1161/CIRCOUTCOMES.116.002756

Abstract

Background: The use of transcatheter aortic valve replacement (TAVR) to treat aortic stenosis in the United States is growing, yet little is known about the variation in procedural outcomes in community practice. We developed a TAVR in-hospital mortality risk model and used it to quantify variation in mortality rates across United States (US) TAVR centers.

Methods and results: We analyzed data from 22 248 TAVR procedures performed at 318 sites participating in the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry (November 2011 to October 2014). A Bayesian hierarchical model was developed to estimate hospital-specific risk-adjusted mortality rates adjusting for 40 patient baseline factors. A total of 1130 in-hospital deaths (5.1%) were observed. Reliability-adjusted risk-adjusted mortality rate estimates ranged from 3.4% to 7.7% with an interquartile range of 4.8% to 5.4%. A patient's predicted odds of dying was 80% higher if treated by a hospital 1 standard deviation above the mean compared with a hospital 1 standard deviation below the mean (odds ratio =1.8; 95% credible interval, 1.4%-2.2%).

Conclusions: Risk modeling of TAVR in-hospital mortality revealed variation in risk-adjusted mortality rates during the US early commercial experience. Transcatheter Valve Therapy Registry analyses using this model will support research, feedback reporting, and the identification of factors associated with quality.

Keywords: aortic stenosis; case-mix adjustment; outcomes analysis; outcomes research; transcatheter aortic valve replacement.

MeSH terms

Aged
Aged, 80 and over
Aortic Valve Stenosis / mortality
Aortic Valve Stenosis / surgery*
Bayes Theorem
Female
Health Services Research
Healthcare Disparities / trends*
Hospital Mortality / trends*
Hospitals / trends*
Humans
Logistic Models
Male
Markov Chains
Monte Carlo Method
Multivariate Analysis
Odds Ratio
Process Assessment, Health Care / trends*
Quality Indicators, Health Care / trends*
Registries
Risk Assessment
Risk Factors
Time Factors
Transcatheter Aortic Valve Replacement / adverse effects
Transcatheter Aortic Valve Replacement / mortality*
Transcatheter Aortic Valve Replacement / trends*
Treatment Outcome