No TRIFling Matter on STING

Gil Ju Seo; Younho Choi; Jae U Jung

doi:10.1016/j.chom.2016.08.009

No TRIFling Matter on STING

Cell Host Microbe. 2016 Sep 14;20(3):277-278. doi: 10.1016/j.chom.2016.08.009.

Authors

Gil Ju Seo¹, Younho Choi¹, Jae U Jung²

Affiliations

¹ Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
² Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: jaeujung@med.usc.edu.

Abstract

STING is a crucial component of the mammalian innate immune response to microbial infection. In this issue of Cell Host & Microbe, Wang et al. (2016) report that TRIF, an adaptor of Toll-like receptors (TLRs), is essential for STING-mediated innate antiviral immunity as well as pro-protozoal responses.

Publication types

Comment

MeSH terms

Animals
Humans
Immunity, Innate / immunology*
Signal Transduction
Toll-Like Receptors*

Substances

Toll-Like Receptors

Abstract

Publication types

MeSH terms

Substances

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