Serum CA125 and HE4 levels as predictors for optimal interval surgery and platinum sensitivity after neoadjuvant platinum-based chemotherapy in patients with advanced epithelial ovarian cancer

Aurélie Pelissier; Aurélie Roulot; Béatrice Guéry; Claire Bonneau; Dominique Bellet; Roman Rouzier

doi:10.1186/s13048-016-0270-7

Serum CA125 and HE4 levels as predictors for optimal interval surgery and platinum sensitivity after neoadjuvant platinum-based chemotherapy in patients with advanced epithelial ovarian cancer

J Ovarian Res. 2016 Sep 27;9(1):61. doi: 10.1186/s13048-016-0270-7.

Authors

Aurélie Pelissier^{1

2}, Aurélie Roulot³, Béatrice Guéry⁴, Claire Bonneau³, Dominique Bellet⁴, Roman Rouzier^{3

5}

Affiliations

¹ Department of Breast and Gynecological Surgery, Centre René Huguenin, Institut Curie, 35 rue Dailly, 92210, Saint Cloud, France. a.komorek@gmail.com.
² Versailles-St-Quentin-en-Yvelines University, EA 7285: Risques cliniques et sécurité en santé des femmes et en santé périnatale, Versailles, France. a.komorek@gmail.com.
³ Department of Breast and Gynecological Surgery, Centre René Huguenin, Institut Curie, 35 rue Dailly, 92210, Saint Cloud, France.
⁴ Laboratory of Biological Oncology, Centre René Huguenin, Institut Curie, 35 rue Dailly, 92210, Saint Cloud, France.
⁵ Versailles-St-Quentin-en-Yvelines University, EA 7285: Risques cliniques et sécurité en santé des femmes et en santé périnatale, Versailles, France.

Abstract

Background: The aim of this study is to evaluate a new tumour marker, HE4, and to compare it with CA125 in predicting optimal cytoreduction and response to chemotherapy. Thirty patients with advanced epithelial ovarian cancer and multiple sera harvested during neoadjuvant chemotherapy (NAC) were included.

Results: Based on ROC curves analysis, CA125 ≤ 75 UI/ml and HE4 ≤ 252 pmol/L after the 3rd cycles of NAC, with a sensitivity of 93.7 % and a specificity of 92.3 % (PPV = 93.7 % and NPV = 92.3 %), offered the best combination for predicting optimal cytoreduction. In addition, the HE4 value of 115 pmol/L is the best cut-off level for identifying platinum-sensitive patients.

Conclusions: The introduction of HE4 as a new tool for predicting platinum-sensitivity and interval optimal cytoreduction is promising.

Keywords: Advanced ovarian cancer; CA125; HE4; Neoadjuvant chemotherapy; Optimal cytoreduction; Platinum sensitivity; Predictive value.