Abstract
It is generally believed that significant renal ablation leads to hyperfiltration and eventually progressively worsening chronic kidney disease. The data behind this belief have not been scrutinized intensively. More importantly, the above belief leads many physicians to manage patients differently than they otherwise would manage. Here, we examine the data behind whether hyperfiltration occurs when patients lose kidney mass (by excision or by disease) and whether the hyperfiltration is uniformly injurious.
Keywords:
Chronic kidney disease; Hyperfiltration; Renal ablation.
MeSH terms
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Animals
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Disease Progression
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Female
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Fibrosis
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Glomerular Filtration Rate*
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Humans
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Kidney / pathology
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Kidney / physiopathology*
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Kidney / surgery*
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Lupus Nephritis / complications*
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Lupus Nephritis / pathology
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Lupus Nephritis / physiopathology
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Lupus Nephritis / therapy
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Middle Aged
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Nephrectomy / adverse effects*
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Prognosis
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Proteinuria / etiology
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Proteinuria / pathology
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Proteinuria / physiopathology
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Renal Dialysis
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Renal Insufficiency, Chronic / etiology*
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Renal Insufficiency, Chronic / pathology
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Renal Insufficiency, Chronic / physiopathology
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Renal Insufficiency, Chronic / therapy
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Risk Factors