Peritoneal carcinomatosis of colorectal cancer: novel clinical and molecular outcomes

Abstract

Background: The objective of this study was to identify the prognostic impact of parameters in peritoneal carcinomatosis from colorectal cancer.

Methods: We collected data from patients treated by cytoreductive surgery and Hyperthermic Intraperitoneal Chemotherapy for peritoneal carcinomatosis secondary to colorectal cancer.

Results: Ninety-one procedures were performed. In univariate analysis, an increased peritoneal cancer index was associated with decreased survival (P < .001). The presence of signet ring cells was associated to a decrease in survival from 45.8 to 12.1 months (P < .001). Microsatellite sequences instability status was the only molecular prognostic factor correlated with an increase in median disease-free survival: 12.4 vs 24.9 months (P = .01). The presence of a mucinous component was associated with a decreased of survival from 51.9 to 35.1 months (P = .02).

Conclusions: Clinical factors were affecting the survival of patients. The absence of signet ring cells and mucinous component and the presence of microsatellite sequences instability may be favorable prognostic factors.

Keywords: Colorectal cancer; HIPEC; KRAS; MSI; Peritoneal carcinomatosis; Signet ring cell.