Transmission of chromosomally integrated human herpesvirus 6 via cord blood transplantation

Yuji Yamada; Tomoo Osumi; Ken-Ichi Imadome; Etsuko Takahashi; Tamae Ohye; Tetsushi Yoshikawa; Daisuke Tomizawa; Motohiro Kato; Kimikazu Matsumoto

doi:10.1111/tid.12636

Transmission of chromosomally integrated human herpesvirus 6 via cord blood transplantation

Transpl Infect Dis. 2017 Feb;19(1). doi: 10.1111/tid.12636. Epub 2016 Dec 25.

Authors

Yuji Yamada¹, Tomoo Osumi¹, Ken-Ichi Imadome², Etsuko Takahashi², Tamae Ohye³, Tetsushi Yoshikawa⁴, Daisuke Tomizawa¹, Motohiro Kato¹, Kimikazu Matsumoto¹

Affiliations

¹ Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
² Division of Advanced Medicine for Virus Infections, National Research Institute for Child Health and Development, Tokyo, Japan.
³ Department of Molecular Laboratory Medicine, Faculty of Medical Technology, School of Health Sciences, Fujita Health University, Toyoake, Japan.
⁴ Department of Pediatrics, Fujita Health University, Toyoake, Japan.

PMID: 27859994
DOI: 10.1111/tid.12636

Abstract

Chromosomally integrated human herpesvirus 6 (ciHHV-6) can be transmitted via allogeneic hematopoietic cell transplantation. To date, only a few cases have been reported. Here, we report a case identified as transmission of ciHHV-6 via cord blood transplantation. Distinguishing transmission of ciHHV-6 from HHV-6 reactivation in cases with high titer of HHV-6 DNA load after transplantation is important to prevent unnecessary exposure to antiviral drugs that could be toxic.

Keywords: chromosomally integrated HHV-6; cord blood transplantation; hematopoietic cell transplantation; human herpesvirus 6 (HHV-6); real-time quantitative polymerase chain reaction.

Publication types

Case Reports

MeSH terms

Acyclovir / administration & dosage
Acyclovir / analogs & derivatives
Acyclovir / therapeutic use
Antibiotic Prophylaxis
Antiviral Agents / administration & dosage
Antiviral Agents / therapeutic use
Busulfan / adverse effects
Busulfan / therapeutic use
Child, Preschool
Chromosomes, Human, Pair 22 / virology*
Cord Blood Stem Cell Transplantation / adverse effects*
DNA, Viral / isolation & purification
Exanthema / blood
Exanthema / virology
Fetal Blood / virology*
Fever / blood
Fever / virology
Herpesvirus 6, Human / genetics*
Herpesvirus 6, Human / isolation & purification
Humans
Immunocompromised Host
Male
Melphalan / adverse effects
Melphalan / therapeutic use
Myeloablative Agonists / adverse effects*
Myeloablative Agonists / therapeutic use
Roseolovirus Infections / blood
Roseolovirus Infections / genetics
Roseolovirus Infections / transmission*
Roseolovirus Infections / virology
Transplantation Conditioning / adverse effects*
Unrelated Donors
Valacyclovir
Valine / administration & dosage
Valine / analogs & derivatives
Valine / therapeutic use
Viral Load
Virus Integration*

Substances

Antiviral Agents
DNA, Viral
Myeloablative Agonists
Busulfan
Valine
Valacyclovir
Melphalan
Acyclovir