The history of the pulmonary diffusing capacity for nitric oxide DL,NO

Colin Borland; Hervé Guénard

doi:10.1016/j.resp.2016.11.014

The history of the pulmonary diffusing capacity for nitric oxide DL,NO

Respir Physiol Neurobiol. 2017 Jul:241:3-6. doi: 10.1016/j.resp.2016.11.014. Epub 2016 Dec 1.

Authors

Colin Borland¹, Hervé Guénard²

Affiliations

¹ Department of Medicine University of Cambridge, UK and Hinchingbrooke Hospital, Huntingdon, UK. Electronic address: colinborland@nhs.net.
² Physiologie et EFR, Université Bordeaux 2 et CHU Bordeaux, France. Electronic address: guenardherve@hotmail.com.

PMID: 27916736
DOI: 10.1016/j.resp.2016.11.014

Abstract

The DL,NO (TL,NO) had its unexpected origins in the Paris "events" of 1968 and the unsuccessful efforts of the UK tobacco industry in the 1970's to create a "safer cigarette". Adoption of the technique has been slow due to the instability of NO in air, lack of standardisation of the technique and lack of agreement as to whether DL,NO is equal to or merely reflects membrane diffusing capacity (DM). With the availability of inexpensive analysers, standardisation of the technique and publication of reference equations we believe that its worldwide use will increase.

Keywords: Carbon monoxide; Diffusing capacity; History; Nitric oxide.

MeSH terms

Carbon Monoxide*
Humans
Nitric Oxide*
Pulmonary Diffusing Capacity / methods*

Substances

Nitric Oxide
Carbon Monoxide