CO2BOLD assessment of moyamoya syndrome: Validation with single photon emission computed tomography and positron emission tomography imaging

Alain Pellaton; Philippe Bijlenga; Laurie Bouchez; Victor Cuvinciuc; Isabelle Barnaure; Valentina Garibotto; Karl-Olof Lövblad; Sven Haller

doi:10.4329/wjr.v8.i11.887

CO₂BOLD assessment of moyamoya syndrome: Validation with single photon emission computed tomography and positron emission tomography imaging

World J Radiol. 2016 Nov 28;8(11):887-894. doi: 10.4329/wjr.v8.i11.887.

Authors

Alain Pellaton¹, Philippe Bijlenga¹, Laurie Bouchez¹, Victor Cuvinciuc¹, Isabelle Barnaure¹, Valentina Garibotto¹, Karl-Olof Lövblad¹, Sven Haller¹

Affiliation

¹ Alain Pellaton, Laurie Bouchez, Victor Cuvinciuc, Isabelle Barnaure, Karl-Olof Lövblad, Sven Haller, Diagnostic and Interventional Neuroradiology, Geneva University Hospitals, 1211 Geneva, Switzerland.

Abstract

Aim: To compare the assessment of cerebrovascular reserve (CVR) using CO₂BOLD magnetic resonance imaging (MRI) vs positron emission tomography (PET) and single photon emission computed tomography (SPECT) as reference standard.

Methods: Ten consecutive patients (8 women, mean age of 41 ± 26 years) with moyamoya syndrome underwent 14 pre-surgical evaluations for external-internal carotid artery bypass surgery. CVR was assessed using CO₂BOLD and PET (4)/SPECT (11) with a maximum interval of 36 d, and evaluated by two experienced neuroradiologists.

Results: The inter-rater agreement was 0.81 for SPECT (excellent), 0.43 for PET (fair) and 0.7 for CO₂BOLD (good). In 9/14 cases, there was a correspondence between CO₂BOLD and PET/SPECT. In 4/14 cases, CVR was over-estimated in CO₂BOLD, while in 1/14 case, CVR was underestimated in CO₂BOLD. The sensitivity of CO₂BOLD was 86% and a specificity of 43%.

Conclusion: CO₂BOLD can be used for pre-surgical assessment of CVR in patients with moyamoya syndrome and combines the advantages of absent irradiation, high availability of MRI and assessment of brain parenchyma, cerebral vessels and surrogate CVR in one stop.

Keywords: CO2BOLD; Cerebrovascular reserve; Moyamoya; Vascular reserve.