Anisotropic phantom to calibrate high-q diffusion MRI methods

M E Komlosh; D Benjamini; A S Barnett; V Schram; F Horkay; A V Avram; P J Basser

doi:10.1016/j.jmr.2016.11.017

Anisotropic phantom to calibrate high-q diffusion MRI methods

J Magn Reson. 2017 Feb:275:19-28. doi: 10.1016/j.jmr.2016.11.017. Epub 2016 Nov 30.

Authors

M E Komlosh¹, D Benjamini², A S Barnett², V Schram³, F Horkay², A V Avram², P J Basser²

Affiliations

¹ Section on Quantitative Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA; Center for Neuroscience and Regenerative Medicine, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, Bethesda, MD, USA. Electronic address: komloshm@mail.nih.gov.
² Section on Quantitative Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
³ Microscopy and Imaging Core, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

Abstract

A silicon oil-filled glass capillary array is proposed as an anisotropic diffusion MRI phantom. Together with a computational/theoretical pipeline these provide a gold standard for calibrating and validating high-q diffusion MRI experiments. The phantom was used to test high angular resolution diffusion imaging (HARDI) and double pulsed-field gradient (d-PFG) MRI acquisition schemes. MRI-based predictions of microcapillary diameter using both acquisition schemes were compared with results from optical microscopy. This phantom design can be used for quality control and quality assurance purposes and for testing and validating proposed microstructure imaging experiments and the processing pipelines used to analyze them.

Keywords: Anisotropic diffusion; DDE; Diffusion; MRI; Microstructure; Phantom; d-PFG.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Algorithms
Anisotropy
Calibration
Capillaries / anatomy & histology
Diffusion Magnetic Resonance Imaging / methods*
Electromagnetic Fields
Image Processing, Computer-Assisted
Phantoms, Imaging*
Porosity
Reproducibility of Results

Abstract

Publication types

MeSH terms

Grants and funding