Gain of 12p encompassing CCND2 is associated with gemistocytic histology in IDH mutant astrocytomas

Felix Sahm; Andrey Korshunov; Daniel Schrimpf; Damian Stichel; David T W Jones; David Capper; Christian Koelsche; David Reuss; Annekathrin Kratz; Kristin Huang; Annika K Wefers; Matthias Schick; Melanie Bewerunge-Hudler; Michel Mittelbronn; Michael Platten; Daniel Hänggi; Astrid Jeibmann; Andreas Unterberg; Christel Herold-Mende; Stefan M Pfister; Sebastian Brandner; Wolfgang Wick; Andreas von Deimling

doi:10.1007/s00401-016-1657-7

Gain of 12p encompassing CCND2 is associated with gemistocytic histology in IDH mutant astrocytomas

Acta Neuropathol. 2017 Feb;133(2):325-327. doi: 10.1007/s00401-016-1657-7. Epub 2016 Dec 20.

Authors

Felix Sahm^{1

2}, Andrey Korshunov³, Daniel Schrimpf^{4

3}, Damian Stichel^{4

3}, David T W Jones⁵, David Capper^{4

3}, Christian Koelsche^{4

3}, David Reuss^{4

3}, Annekathrin Kratz^{4

3}, Kristin Huang^{4

3}, Annika K Wefers^{4

3}, Matthias Schick⁶, Melanie Bewerunge-Hudler⁶, Michel Mittelbronn⁷, Michael Platten^{8

9

10}, Daniel Hänggi¹¹, Astrid Jeibmann¹², Andreas Unterberg¹³, Christel Herold-Mende¹³, Stefan M Pfister^{5

14}, Sebastian Brandner¹⁵, Wolfgang Wick^{8

16}, Andreas von Deimling^{17

18}

Affiliations

¹ Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany. Felix.Sahm@med.uni-heidelberg.de.
² Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 224, 69120, Heidelberg, Germany. Felix.Sahm@med.uni-heidelberg.de.
³ Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 224, 69120, Heidelberg, Germany.
⁴ Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.
⁵ Division of Pediatric Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁶ Genomics and Proteomics Core Facility, Microarray Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁷ Neurological Institute (Edinger Institute), University Hospital Frankfurt, Frankfurt, Germany.
⁸ Neurology Clinic, University Hospital Heidelberg, Heidelberg, Germany.
⁹ Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹⁰ Neurology Clinic, University Hospital Mannheim, Mannheim, Germany.
¹¹ Department of Neurosurgery, University Hospital Mannheim, Mannheim, Germany.
¹² Institute of Neuropathology, University Hospital Münster, Münster, Germany.
¹³ Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.
¹⁴ Department of Pediatric Oncology, Haematology and Immunology, Heidelberg University Hospital, and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
¹⁵ Division of Neuropathology of the UCL Institute of Neurology in London, London, UK.
¹⁶ Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹⁷ Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany. andreas.vondeimling@med.uni-heidelberg.de.
¹⁸ Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 224, 69120, Heidelberg, Germany. andreas.vondeimling@med.uni-heidelberg.de.

PMID: 28000032
DOI: 10.1007/s00401-016-1657-7

No abstract available

MeSH terms

Astrocytoma / genetics*
Astrocytoma / pathology*
Brain Neoplasms / genetics*
Brain Neoplasms / pathology*
Cyclin D2 / genetics*
DNA Copy Number Variations
Humans
Isocitrate Dehydrogenase / genetics
Mutation

Substances

CCND2 protein, human
Cyclin D2
Isocitrate Dehydrogenase
IDH1 protein, human