Mycobacterium genavense-induced spindle cell pseudotumor in a pediatric hematopoietic stem cell transplant recipient: Case report and review of the literature

Ritika Coelho; Rabi Hanna; Aron Flagg; Lisa M Stempak; Sarah Ondrejka; Gary W Procop; Susan Harrington; Anthony Zembillas; Karissa Kusick; Blanca E Gonzalez

doi:10.1111/tid.12656

Mycobacterium genavense-induced spindle cell pseudotumor in a pediatric hematopoietic stem cell transplant recipient: Case report and review of the literature

Transpl Infect Dis. 2017 Apr;19(2). doi: 10.1111/tid.12656. Epub 2017 Mar 6.

Authors

Affiliations

¹ Center for Pediatric Infectious Diseases, Cleveland Clinic Children's Hospital, Cleveland, OH, USA.
² Centers for Hematology - Oncology, Cleveland Clinic Children's Hospital, Cleveland, OH, USA.
³ Departments of Pathology and Laboratory Medicine, Cleveland Clinic Children's Hospital, Cleveland, OH, USA.
⁴ Department of Pharmacy, Cleveland Clinic Children's Hospital, Cleveland, OH, USA.

PMID: 28039955
DOI: 10.1111/tid.12656

Abstract

We describe the first reported pediatric patient to our knowledge with a spindle cell pseudotumor caused by Mycobacterium genavense in a hematopoietic stem cell transplant recipient, and review the literature of such an entity in the transplant population.

Keywords: Mycobacterium genavense; hematopoietic stem cell transplant; pediatrics; spindle cell pseudotumor.

Publication types

Case Reports
Review

MeSH terms

Abdomen
Adolescent
Alemtuzumab
Antibiotic Prophylaxis
Antibiotics, Antitubercular / therapeutic use
Antibodies, Monoclonal, Humanized / adverse effects
Antibodies, Monoclonal, Humanized / therapeutic use
Bone Marrow Transplantation / adverse effects
Bronchoalveolar Lavage Fluid / microbiology
Cyclosporine / adverse effects
Cyclosporine / therapeutic use
Diabetes Mellitus, Type 1 / congenital
Diabetes Mellitus, Type 1 / surgery
Diarrhea / surgery
Genetic Diseases, X-Linked / surgery
Graft Rejection / surgery
Graft vs Host Disease / therapy*
Hematopoietic Stem Cell Transplantation / adverse effects*
Histiocytes / microbiology*
Humans
Immune System Diseases / congenital
Immune System Diseases / surgery
Immunosuppressive Agents / adverse effects*
Immunosuppressive Agents / therapeutic use
Lymph Nodes / microbiology*
Lymph Nodes / pathology
Male
Melphalan / adverse effects
Melphalan / therapeutic use
Mycobacterium Infections, Nontuberculous / drug therapy
Mycobacterium Infections, Nontuberculous / microbiology*
Mycobacterium Infections, Nontuberculous / pathology
Mycophenolic Acid / adverse effects
Mycophenolic Acid / therapeutic use
Nontuberculous Mycobacteria / isolation & purification
Nontuberculous Mycobacteria / pathogenicity*
Photopheresis
Polymerase Chain Reaction
Transplantation Conditioning / adverse effects*
Transplantation Conditioning / methods
Vidarabine / adverse effects
Vidarabine / analogs & derivatives
Vidarabine / therapeutic use

Substances

Antibiotics, Antitubercular
Antibodies, Monoclonal, Humanized
Immunosuppressive Agents
Alemtuzumab
Cyclosporine
Vidarabine
Mycophenolic Acid
fludarabine
Melphalan

Supplementary concepts

Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome