Nabscessins A and B, Aminocyclitol Derivatives from Nocardia abscessus IFM 10029T

Shoko Hara; Naoki Ishikawa; Yasumasa Hara; Tatsuo Nehira; Kanae Sakai; Tohru Gonoi; Masami Ishibashi

doi:10.1021/acs.jnatprod.6b00935

Nabscessins A and B, Aminocyclitol Derivatives from Nocardia abscessus IFM 10029^T

J Nat Prod. 2017 Feb 24;80(2):565-568. doi: 10.1021/acs.jnatprod.6b00935. Epub 2017 Jan 23.

Authors

Shoko Hara¹, Naoki Ishikawa¹, Yasumasa Hara¹, Tatsuo Nehira², Kanae Sakai³, Tohru Gonoi³, Masami Ishibashi¹

Affiliations

¹ Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
² Graduate School of Integrated Arts and Sciences, Hiroshima University , 1-7-1 Kagamiyama, Higashi-hiroshima, 739-8521, Japan.
³ Medical Mycology Research Center, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8673, Japan.

PMID: 28112922
DOI: 10.1021/acs.jnatprod.6b00935

Abstract

Two new aminocyclitol amide derivatives, nabscessins A (1) and B (2), were isolated from the culture broth of a pathogenic actinomycete species, Nocardia abscessus IFM 10029^T. The structures of nabscessins A and B were elucidated by spectral studies, and the compounds showed antifungal activity against Cryptococcus neoformans, with IC₅₀ values of 32 and 16 μg/mL, respectively.

MeSH terms

Actinobacteria / chemistry
Antifungal Agents / chemistry
Antifungal Agents / isolation & purification*
Antifungal Agents / pharmacology*
Cryptococcus neoformans / drug effects
Cyclitols / chemistry
Cyclitols / isolation & purification*
Microbial Sensitivity Tests
Molecular Structure
Nocardia / chemistry*
Phylogeny
RNA, Ribosomal, 16S / chemistry

Substances

Antifungal Agents
Cyclitols
RNA, Ribosomal, 16S
nabscessin A
nabscessin B