Aquaporin-2 membrane targeting: still a conundrum

Am J Physiol Renal Physiol. 2017 Apr 1;312(4):F744-F747. doi: 10.1152/ajprenal.00010.2017. Epub 2017 Feb 8.

Abstract

The targeting of the water channel aquaporin-2 (AQP2) to the apical plasma membrane of kidney collecting duct principal cells is regulated mainly by the antidiuretic peptide hormone arginine vasopressin (AVP). This process is of crucial importance for the maintenance of body water homeostasis. In this brief review we assess the role of cyclic adenosine monophosphate (cAMP) and discuss the emerging concept that type 2 AVP receptor (V2R)-mediated AQP2 trafficking is cAMP-independent.

Keywords: 7-transmembrane receptors; aquaporin; cAMP; cell signaling; vasopressin.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aquaporin 2 / metabolism*
  • Arginine Vasopressin / metabolism
  • Body Water / metabolism*
  • Cell Membrane / metabolism*
  • Cyclic AMP / metabolism
  • Epithelial Cells / metabolism*
  • Humans
  • Kidney Tubules, Collecting / metabolism*
  • Protein Transport
  • Receptors, Vasopressin / metabolism
  • Second Messenger Systems
  • Water-Electrolyte Balance*

Substances

  • Aquaporin 2
  • Receptors, Vasopressin
  • Arginine Vasopressin
  • Cyclic AMP