Live Cell Therapy as Potential Risk Factor for Q Fever

Emerg Infect Dis. 2017 Jul;23(7):1210-1212. doi: 10.3201/eid2307.161693. Epub 2017 Jul 15.

Abstract

During an outbreak of Q fever in Germany, we identified an infected sheep flock from which animals were routinely used as a source for life cell therapy (LCT), the injection of fetal cells or cell extracts from sheep into humans. Q fever developed in 7 LCT recipients from Canada, Germany, and the United States.

Keywords: Canada; Coxiella burnetii; Germany; Q fever; bacteria; fetal tissue; inhalation exposure; intramuscular injection; live cell therapy; occupational exposure; outbreaks; risk factor; sheep; zoonoses.

MeSH terms

  • Adult
  • Animals
  • Cell- and Tissue-Based Therapy / adverse effects*
  • Coxiella burnetii* / immunology
  • Disease Outbreaks
  • Female
  • Germany / epidemiology
  • Humans
  • Male
  • Middle Aged
  • Q Fever / diagnosis
  • Q Fever / epidemiology*
  • Q Fever / etiology*
  • Risk Factors
  • Sheep
  • Sheep Diseases / microbiology
  • Zoonoses