Abstract
d-Alpha tocopheryl succinate (vitamin E succinate), which inhibited growth and survival, and induced differentiation in murine B-16 melanoma cells in culture, increased adenosine 3',5'cyclic monophosphate-(cAMP)-dependent protein kinase (PK) activity without increasing the cellular cAMP level. Prostaglandin (PG)A2, which produced changes in melanoma cells similar to those produced by vitamin E succinate, also increased cAMP-dependent PK activity without changing the intracellular level of cAMP.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Cell Survival / drug effects
-
Cyclic AMP / analysis
-
Melanoma, Experimental / enzymology*
-
Melanoma, Experimental / pathology
-
Mice
-
Prostaglandins A / pharmacology
-
Protein Kinases / analysis*
-
Tocopherols
-
Tumor Cells, Cultured / drug effects
-
Vitamin E / analogs & derivatives*
-
Vitamin E / pharmacology
Substances
-
Prostaglandins A
-
Vitamin E
-
Cyclic AMP
-
Protein Kinases
-
prostaglandin A2
-
Tocopherols