Effect of alpha tocopheryl succinate on cyclic AMP-dependent protein kinase activity in murine B-16 melanoma cells in culture

Cancer Lett. 1988 Mar;39(2):129-36. doi: 10.1016/0304-3835(88)90097-3.

Abstract

d-Alpha tocopheryl succinate (vitamin E succinate), which inhibited growth and survival, and induced differentiation in murine B-16 melanoma cells in culture, increased adenosine 3',5'cyclic monophosphate-(cAMP)-dependent protein kinase (PK) activity without increasing the cellular cAMP level. Prostaglandin (PG)A2, which produced changes in melanoma cells similar to those produced by vitamin E succinate, also increased cAMP-dependent PK activity without changing the intracellular level of cAMP.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Survival / drug effects
  • Cyclic AMP / analysis
  • Melanoma, Experimental / enzymology*
  • Melanoma, Experimental / pathology
  • Mice
  • Prostaglandins A / pharmacology
  • Protein Kinases / analysis*
  • Tocopherols
  • Tumor Cells, Cultured / drug effects
  • Vitamin E / analogs & derivatives*
  • Vitamin E / pharmacology

Substances

  • Prostaglandins A
  • Vitamin E
  • Cyclic AMP
  • Protein Kinases
  • prostaglandin A2
  • Tocopherols