Acute Rejection Phenotypes in the Current Era of Immunosuppression: A Single-Center Analysis

Caroline Wehmeier; Patrizia Amico; Patricia Hirt-Minkowski; Argyrios Georgalis; Gideon Höenger; Thomas Menter; Michael Mihatsch; Felix Burkhalter; Juerg Steiger; Michael Dickenmann; Helmut Hopfer; Stefan Schaub

doi:10.1097/TXD.0000000000000650

Acute Rejection Phenotypes in the Current Era of Immunosuppression: A Single-Center Analysis

Transplant Direct. 2017 Feb 9;3(3):e136. doi: 10.1097/TXD.0000000000000650. eCollection 2017 Mar.

Affiliations

¹ Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland.
² Institute for Pathology, University Hospital Basel, Basel, Switzerland.

Abstract

Background: Besides 'definitive rejection', the Banff classification includes categories for 'suspicious for rejection' phenotypes. The aim of this study was to determine the frequency and phenotypes of rejection episodes in 316 consecutive renal transplants from 2009 to 2014 grouped into patients without/with pretransplant HLA-DSA (ptDSA_neg, n = 251; ptDSA_pos, n = 65).

Methods: All adequate indication (n = 125) and surveillance biopsies (n = 538) performed within the first year posttransplant were classified according to the current Banff criteria.

Results: 'Suspicious for rejection' phenotypes were 3 times more common than 'definitive rejection' phenotypes in biopsies from ptDSA_neg patients (35% vs 11%) and equally common in biopsies from ptDSA_pos patients (25% vs 27%). In both groups, 'suspicious for rejection' phenotypes were more frequent in surveillance than in indication biopsies (28% vs 16% in ptDSA_neg patients, and 37% vs 29% in ptDSA_pos patients). 'Borderline changes: 'Suspicious' for acute T-cell mediated rejection' (91%) were the dominant 'suspicious for rejection' phenotype in ptDSA_neg patients, whereas 'borderline changes' (58%) and 'suspicious for acute/active antibody-mediated rejection' (42%) were equally frequent in biopsies from ptDSA_pos patients. Inclusion of 'suspicious for rejection' phenotypes increased the 1-year incidence of clinical (ptDSA_neg patients: 18% vs 8%, P = 0.0005; ptDSA_pos patients: 24% vs 18%, P = 0.31) and (sub)clinical rejection (ptDSA_neg patients: 59% vs 22%, P < 0.0001; ptDSA_pos patients: 68% vs 40%, P = 0.004).

Conclusions: 'Suspicious for rejection' phenotypes are very common in the current era and outnumber the frequency of 'definitive rejection' within the first year posttransplant.