Abstract
Quercetin is an effective inhibitor of human myeloperoxidase (MPO) activity, both with purified enzyme (IC50 = 3.5 microM) and in a system using stimulated human neutrophils. Quercetin is significantly more potent than three other related compounds (rutin, rutin sulfate and troxerutin) and than methimazole, a previously-known myeloperoxidase inhibitor. The inhibitory activity of quercetin is of the competitive type. Moreover, quercetin is directly able to scavenge hypochlorous acid (HOCl), a chlorinated species generated by the MPO/H2O2/Cl- system.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Chemical Phenomena
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Chemistry
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Flavonoids / pharmacology*
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Humans
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Hydroxyethylrutoside / analogs & derivatives
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Hydroxyethylrutoside / pharmacology
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Hypochlorous Acid
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Methimazole / pharmacology
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Neutrophils / enzymology
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Peroxidase / antagonists & inhibitors*
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Quercetin / pharmacology*
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Rutin / analogs & derivatives
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Rutin / pharmacology
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Spectrophotometry
Substances
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Flavonoids
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Hydroxyethylrutoside
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rutin sulfate
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Methimazole
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Rutin
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Hypochlorous Acid
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troxerutin
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Quercetin
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Peroxidase