Unusual antigen presentation offers new insight into HIV vaccine design

Curr Opin Immunol. 2017 Jun:46:75-81. doi: 10.1016/j.coi.2017.04.009. Epub 2017 May 12.

Abstract

Recent findings with a rhesus monkey cytomegalovirus based simian immunodeficiency virus vaccine have identified strong CD8+ T cell responses that are restricted by MHC-E. Also mycobacteria specific CD8+ T cells, that are MHC-E restricted, have been identified. MHC-E therefore can present a wide range of epitope peptides to CD8+ T cells, alongside its well defined role in presenting a conserved MHC-class I signal peptide to the NKG2A/C-CD94 receptor on natural killer cells. Here we explore the antigen processing pathways involved in these atypical T cell responses.

Publication types

  • Review

MeSH terms

  • AIDS Vaccines / immunology*
  • Animals
  • Antigen Presentation / immunology*
  • CD8-Positive T-Lymphocytes / immunology
  • Epitopes, T-Lymphocyte / chemistry
  • Epitopes, T-Lymphocyte / immunology
  • HIV / immunology*
  • HIV Antigens / chemistry
  • HIV Antigens / immunology*
  • HIV Infections / genetics
  • HIV Infections / immunology*
  • HIV Infections / metabolism
  • HIV Infections / prevention & control
  • Histocompatibility Antigens Class I / immunology
  • Host-Pathogen Interactions / immunology
  • Humans
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocyte Subsets / metabolism

Substances

  • AIDS Vaccines
  • Epitopes, T-Lymphocyte
  • HIV Antigens
  • Histocompatibility Antigens Class I