Size Doesn't Matter: Shorter Antibody Loops Can Infiltrate HIV's Env Apex Defenses

Jinal N Bhiman; Penny L Moore

doi:10.1016/j.immuni.2017.04.012

Size Doesn't Matter: Shorter Antibody Loops Can Infiltrate HIV's Env Apex Defenses

Immunity. 2017 May 16;46(5):762-764. doi: 10.1016/j.immuni.2017.04.012.

Authors

Jinal N Bhiman¹, Penny L Moore²

Affiliations

¹ Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service (NHLS), Johannesburg 2131, South Africa; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2050, South Africa.
² Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service (NHLS), Johannesburg 2131, South Africa; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2050, South Africa; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu Natal, Durban 4013, South Africa. Electronic address: pennym@nicd.ac.za.

PMID: 28514679
DOI: 10.1016/j.immuni.2017.04.012

Abstract

An HIV vaccine that elicits broadly neutralizing antibodies, which often have unusual structural features, has not yet been developed. In Immunity this month, Cale et al., 2017 describe how a new mode of binding allows a conventional antibody to infiltrate HIV's armor.

Publication types

Comment

MeSH terms

AIDS Vaccines / chemistry
Antibodies, Neutralizing / immunology
HIV Antibodies / immunology*
HIV Infections / immunology
HIV-1 / immunology*
Humans

Substances

AIDS Vaccines
Antibodies, Neutralizing
HIV Antibodies