Thrombotic thrombocytopenic purpura related to ADAMTS13 deficiency, and successful treatment in a chimpanzee (Pan troglodytes verus)

J Med Primatol. 2017 Oct;46(5):267-270. doi: 10.1111/jmp.12278. Epub 2017 May 26.

Abstract

A 27-year-old male chimpanzee (Pan troglodytes verus) developed signs of thrombotic thrombocytopenic purpura (TTP). ADAMTS13 deficiency appeared to be the cause of disease. After treatment with high-dose prednisone, haematological values and clinical signs recovered. This is the first description of spontaneous TTP associated with ADAMTS13 deficiency in a non-human primate.

Keywords: Haemolytic anaemia; TTP; VWF; hepatitis C virus; non-human primate; prednisone; thrombocytopenia.

Publication types

  • Case Reports

MeSH terms

  • ADAMTS13 Protein / deficiency*
  • Animals
  • Anticoagulants / therapeutic use*
  • Ape Diseases / drug therapy*
  • Ape Diseases / genetics
  • Diagnosis, Differential
  • Male
  • Pan troglodytes*
  • Prednisone / therapeutic use*
  • Purpura, Thrombotic Thrombocytopenic / drug therapy
  • Purpura, Thrombotic Thrombocytopenic / genetics
  • Purpura, Thrombotic Thrombocytopenic / veterinary*

Substances

  • Anticoagulants
  • ADAMTS13 Protein
  • Prednisone