Frequent malaria illness episodes in two Malawian patients on antiretroviral therapy soon after stopping cotrimoxazole preventive therapy

Malawi Med J. 2017 Mar;29(1):57-60. doi: 10.4314/mmj.v29i1.12.

Abstract

We describe two Malawian adults on successful antiretroviral therapy who experienced frequent malaria episodes after stopping cotrimoxazole prophylaxis. We argue that, in addition to stopping cotrimoxazole, diminished malaria immunity and drug interactions between efavirenz and artemether-lumefantrine may have played a causative role in the recurrent malaria our patients experienced.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-HIV Agents / administration & dosage*
  • Anti-HIV Agents / therapeutic use
  • Antimalarials / therapeutic use
  • Antiretroviral Therapy, Highly Active / methods*
  • Drug Interactions
  • Female
  • HIV Infections / complications*
  • HIV Infections / drug therapy*
  • Humans
  • Malaria / diagnosis*
  • Malaria / drug therapy
  • Middle Aged
  • Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use*

Substances

  • Anti-HIV Agents
  • Antimalarials
  • Trimethoprim, Sulfamethoxazole Drug Combination