Relative Nephrotoxicity of Different Contrast Media

Iram Aqeel; Amarinder S Garcha; Michael R Rudnick

doi:10.1016/j.iccl.2014.04.001

Relative Nephrotoxicity of Different Contrast Media

Interv Cardiol Clin. 2014 Jul;3(3):349-356. doi: 10.1016/j.iccl.2014.04.001. Epub 2014 Jun 28.

Authors

Iram Aqeel¹, Amarinder S Garcha¹, Michael R Rudnick²

Affiliations

¹ Renal, Electrolyte and Hypertension Division, University of Pennsylvania, 3400 Spruce Street, One Founders, Philadelphia, PA 19104, USA.
² Renal, Electrolyte and Hypertension Division, University of Pennsylvania, 3400 Spruce Street, One Founders, Philadelphia, PA 19104, USA. Electronic address: Michael.rudnick@uphs.upenn.edu.

PMID: 28582219
DOI: 10.1016/j.iccl.2014.04.001

Abstract

Contrast-induced nephropathy (CIN) is a common cause of acute kidney injury among hospitalized patients. High-osmolar contrast agents are associated with increased risk of CIN. Low-osmolar (LOCM) and iso-osmolar (IOCM) agents show no difference in the incidence of CIN, even among high-risk patients. This finding suggests that factors other than osmolality may play a role in the pathogenesis of CIN. The use of either LOCM or IOCM agents is recommended in high-risk patients.

Keywords: Contrast media; Contrast-induced nephropathy; Nephrotoxicity; Osmolar contrast agent.

Publication types

Review