Comparison of circadian, weekly, and seasonal variations of electrical storms and single events of ventricular fibrillation in patients with Brugada syndrome

Yoshiyasu Aizawa; Seiji Takatsuki; Yoshiaki Kaneko; Takashi Noda; Yoshinori Katsumata; Takahiko Nishiyama; Takehiro Kimura; Nobuhiro Nishiyama; Kotaro Fukumoto; Shinichi Niwano; Takashi Kurita; Takeshi Mitsuhashi; Shiro Kamakura; Akihiko Shimizu; Minoru Horie; Yoshifusa Aizawa; Keiichi Fukuda

doi:10.1016/j.ijcha.2016.05.008

Comparison of circadian, weekly, and seasonal variations of electrical storms and single events of ventricular fibrillation in patients with Brugada syndrome

Int J Cardiol Heart Vasc. 2016 May 11:11:104-110. doi: 10.1016/j.ijcha.2016.05.008. eCollection 2016 Jun.

Authors

Yoshiyasu Aizawa¹, Seiji Takatsuki¹, Yoshiaki Kaneko², Takashi Noda³, Yoshinori Katsumata¹, Takahiko Nishiyama¹, Takehiro Kimura¹, Nobuhiro Nishiyama¹, Kotaro Fukumoto¹, Shinichi Niwano⁴, Takashi Kurita⁵, Takeshi Mitsuhashi⁶, Shiro Kamakura³, Akihiko Shimizu⁷, Minoru Horie⁸, Yoshifusa Aizawa⁹, Keiichi Fukuda¹

Affiliations

¹ Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
² Gunma University, Gunma, Japan.
³ National Cerebral and Cardiovascular Center, Osaka, Japan.
⁴ Kitasato University, Kanagawa, Japan.
⁵ Kinki University, Osaka, Japan.
⁶ Saitama Medical Center, Jichi Medical University, Saitama, Japan.
⁷ Yamaguchi University, Yamaguchi, Japan.
⁸ Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Shiga, Japan.
⁹ Department of Cardiology, Tachikawa General Hospital, Niigata, Japan.

Abstract

In patients with Brugada syndrome (BS), VF occurred predominantly during the nocturnal period. Some patients also developed ESs. In addition to the circadian rhythm, patients showed weekly and seasonal patterns. The patients with ESs had peak episodes of VF on Saturday and in the winter and spring, while episodes of VF in patients with single VF events occurred most often on Monday with smaller seasonal variation. Except for age, there was no difference in the clinical or ECG characteristics between the patients with ESs and those with single VF episodes.

Keywords: BS, Brugada syndrome; Brugada syndrome; CRBBB, complete right bundle branch block; ECG, electrocardiogram; ES, electrical storm; Electrical storm; ICD, implantable cardioverter defibrillator; IVF, idiopathic ventricular fibrillation; MRI, magnetic resonance imaging; Rhythmicity; SD, standard deviation; Sudden death; VF, ventricular fibrillation; VT, ventricular tachycardia; Ventricular fibrillation.