1 Atta-ur Rahman School of Applied Biosciences (R.D., M.J.H.), National University of Sciences and Technology (NUST), Pakistan; Program in Genetics and Genome Biology (R.D., B.A.M.), Division of Neurology (B.A.M.), Department of Paediatrics, and The Centre for Applied Genomics, Genetics and Genome Biology (S.W., S.W.S.), The Hospital for Sick Children; Department of Molecular Genetics (S.W.S.), and McLaughlin Centre (S.W.S.), University of Toronto, Ontario, Canada; and Department of Pediatrics (M.D.A., R.A.A.), Division of Neurology, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia.