Duration of dual anti-platelet therapy - State of the art after the DAPT and PEGASUS-TIMI 54 trials

Acta Cardiol. 2017 Jun;72(3):256-264. doi: 10.1080/00015385.2017.1305189. Epub 2017 Mar 21.

Abstract

Dual anti-platelet therapy is prescribed in the setting of coronary heart disease for the prevention of stent thrombosis and acute thrombotic events. The optimal duration of dual anti-platelet therapy is still under debate as numerous trials have shown non-inferiority of a strategy of early cessation of one of the agents as compared to the standard practice whereas two larger trials have demonstrated benefit of prolonging dual anti-platelet therapy.

Keywords: Dual antiplatelet therapy; bleeding; stent thrombosis.

Publication types

  • Review

MeSH terms

  • Coronary Restenosis / prevention & control*
  • Drug Therapy, Combination
  • Humans
  • Platelet Aggregation Inhibitors / therapeutic use*
  • Prosthesis Failure
  • Randomized Controlled Trials as Topic*
  • Stents / adverse effects*
  • Thrombolytic Therapy / methods*
  • Treatment Outcome

Substances

  • Platelet Aggregation Inhibitors