A Common Clinical Dilemma: Management of Persistent hrHPV Infection

Yifan Meng; Ding Ma; Peng Wu

doi:10.1016/j.trecan.2017.03.010

A Common Clinical Dilemma: Management of Persistent hrHPV Infection

Trends Cancer. 2017 May;3(5):315-318. doi: 10.1016/j.trecan.2017.03.010. Epub 2017 Apr 24.

Authors

Yifan Meng¹, Ding Ma², Peng Wu³

Affiliations

¹ The Key Laboratory of Cancer Invasion and Metastasis of the Ministry of Education, China, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.
² The Key Laboratory of Cancer Invasion and Metastasis of the Ministry of Education, China, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China. Electronic address: dma@tjh.tjmu.edu.cn.
³ The Key Laboratory of Cancer Invasion and Metastasis of the Ministry of Education, China, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China. Electronic address: pengwu8626@126.com.

PMID: 28718408
DOI: 10.1016/j.trecan.2017.03.010

Abstract

Persistent infection with high-risk human papillomavirus (hrHPV) is a key step in the development of cervical cancer. However, making clinical decisions about how to deal with these cases has become a challenge for obstetrics and gynecology (Ob/Gyn) practitioners. Here, we review the latest research findings and propose possible solutions for the management of persistent hrHPV infections.

Keywords: biomarkers; hrHPV test; human papillomavirus (HPV); next-generation sequencing (NGS); triages.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Female
Humans
Papillomaviridae / genetics*
Papillomavirus Infections / therapy*
Papillomavirus Infections / virology
Pregnancy
Uterine Cervical Dysplasia / etiology*
Uterine Cervical Dysplasia / pathology
Uterine Cervical Dysplasia / virology