Abstract
A woman with extremely drug-resistant tuberculosis treated with a drug regimen including linezolid and bedaquiline during her last 3 weeks of pregnancy gave birth to a child without abnormalities. No fetal toxicities were noted by 2 years after delivery. This drug combination might be safe during the late third trimester of pregnancy.
Keywords:
France; Georgia; MDR TB; Mycobacterium tuberculosis; XDR TB; antimicrobial resistance; bacteria; bedaquiline; case study; linezolid; multidrug-resistant tuberculosis; mycobacteria; pregnancy; respiratory infections; tuberculosis.
MeSH terms
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Adult
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Antitubercular Agents / administration & dosage
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Antitubercular Agents / therapeutic use*
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Diarylquinolines / administration & dosage
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Diarylquinolines / therapeutic use*
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Drug Therapy, Combination
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Extensively Drug-Resistant Tuberculosis / drug therapy*
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Female
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Humans
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Linezolid / administration & dosage
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Linezolid / therapeutic use*
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Mycobacterium tuberculosis / drug effects
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Pregnancy
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Pregnancy Complications, Infectious / drug therapy*
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Pregnancy Complications, Infectious / microbiology
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Tuberculosis, Pulmonary / drug therapy*
Substances
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Antitubercular Agents
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Diarylquinolines
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bedaquiline
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Linezolid