House dust mite allergens Der f and Der p induce IL-31 production by blood-derived T cells from atopic dermatitis patients

Exp Dermatol. 2018 Apr;27(4):393-395. doi: 10.1111/exd.13438. Epub 2017 Nov 7.

Abstract

Aero-allergens, such as house dust mite (HDM), have been suggested to play a role in the initiation of atopic dermatitis (AD)-related skin inflammation. Here, we analysed the proliferation and the cytokine expression of blood-derived T cells from AD and healthy individuals upon HDM-allergen stimulation. The proliferating cells from healthy individuals and AD patients had a significantly different, distinct cytokine profile: in AD blood, we found increased frequencies of HDM-reactive IL-31-producing T cells, as well as a decreased Th1/Th2 and Tc1/Tc2 ratio, suggesting that allergen-specific T cells in blood of chronic AD patients are subject to pre-existent Th2-Tc2 and "Th31-Tc31" programming.

Keywords: atopic dermatitis; house dust mite; interleukin-31.

Publication types

  • Letter

MeSH terms

  • Adult
  • Animals
  • Antigens, Dermatophagoides / pharmacology*
  • CD4 Lymphocyte Count
  • CD8-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / metabolism*
  • Cell Proliferation / drug effects
  • Cells, Cultured
  • Dermatitis, Atopic / blood*
  • Dermatitis, Atopic / immunology
  • Female
  • Humans
  • Interleukins / metabolism*
  • Male
  • Middle Aged
  • Pyroglyphidae
  • Th1 Cells / immunology
  • Th1 Cells / metabolism*
  • Th2 Cells / immunology
  • Th2 Cells / metabolism*
  • Young Adult

Substances

  • Antigens, Dermatophagoides
  • IL31 protein, human
  • Interleukins