Abstract
In a multicenter retrospective study, we sought to determine the optimal vancomycin trough concentration that would impact the duration of methicillin-resistant Staphylococcus aureus bacteremia in children. We found that a median vancomycin trough concentration of <10 µg/mL within the first 72 hours may be associated with a longer duration of bacteremia compared to a median trough concentration of ≥10 µg/mL.
MeSH terms
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Anti-Bacterial Agents / blood
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Anti-Bacterial Agents / pharmacokinetics*
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Anti-Bacterial Agents / therapeutic use
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Area Under Curve
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Bacteremia / blood
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Bacteremia / drug therapy*
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Bacteremia / microbiology
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Child
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Child, Preschool
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Female
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Humans
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Infant
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Male
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Methicillin-Resistant Staphylococcus aureus / drug effects*
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Microbial Sensitivity Tests
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Retrospective Studies
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Staphylococcal Infections / blood
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Staphylococcal Infections / drug therapy*
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Staphylococcal Infections / microbiology
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Vancomycin / blood
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Vancomycin / pharmacokinetics*
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Vancomycin / therapeutic use
Substances
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Anti-Bacterial Agents
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Vancomycin