Association Between Vancomycin Trough Concentrations and Duration of Methicillin-Resistant Staphylococcus aureus Bacteremia in Children

J Pediatric Infect Dis Soc. 2018 Dec 3;7(4):338-341. doi: 10.1093/jpids/pix068.

Abstract

In a multicenter retrospective study, we sought to determine the optimal vancomycin trough concentration that would impact the duration of methicillin-resistant Staphylococcus aureus bacteremia in children. We found that a median vancomycin trough concentration of <10 µg/mL within the first 72 hours may be associated with a longer duration of bacteremia compared to a median trough concentration of ≥10 µg/mL.

Publication types

  • Multicenter Study

MeSH terms

  • Anti-Bacterial Agents / blood
  • Anti-Bacterial Agents / pharmacokinetics*
  • Anti-Bacterial Agents / therapeutic use
  • Area Under Curve
  • Bacteremia / blood
  • Bacteremia / drug therapy*
  • Bacteremia / microbiology
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Male
  • Methicillin-Resistant Staphylococcus aureus / drug effects*
  • Microbial Sensitivity Tests
  • Retrospective Studies
  • Staphylococcal Infections / blood
  • Staphylococcal Infections / drug therapy*
  • Staphylococcal Infections / microbiology
  • Vancomycin / blood
  • Vancomycin / pharmacokinetics*
  • Vancomycin / therapeutic use

Substances

  • Anti-Bacterial Agents
  • Vancomycin