Acute Retinal Necrosis Caused by the Zoster Vaccine Virus

Clin Infect Dis. 2017 Nov 29;65(12):2122-2125. doi: 10.1093/cid/cix683.

Abstract

We report acute retinal necrosis caused by the vaccine Oka strain following immunization of a 78-year-old woman with live zoster vaccine. Whole genome sequencing confirmed the ocular vOka strain to be derived from the vaccine and excluded the presence of new mutations or recombination with wild-type Varicella zoster virus.

Keywords: Varicella zoster virus; retinitis; shingles; vaccine; zoster.

Publication types

  • Case Reports

MeSH terms

  • Acyclovir / administration & dosage
  • Acyclovir / analogs & derivatives
  • Acyclovir / therapeutic use
  • Aged
  • Antiviral Agents / administration & dosage
  • Antiviral Agents / therapeutic use
  • DNA Viruses / genetics
  • DNA Viruses / isolation & purification
  • DNA, Viral
  • Eye / cytology
  • Eye / pathology
  • Eye / virology
  • Female
  • Herpes Zoster / complications*
  • Herpes Zoster / prevention & control
  • Herpes Zoster Vaccine / administration & dosage
  • Herpes Zoster Vaccine / adverse effects*
  • Herpesvirus 3, Human / genetics
  • Herpesvirus 3, Human / isolation & purification*
  • Humans
  • Retinal Necrosis Syndrome, Acute / diagnosis
  • Retinal Necrosis Syndrome, Acute / drug therapy
  • Retinal Necrosis Syndrome, Acute / etiology
  • Retinal Necrosis Syndrome, Acute / virology*
  • Vaccination / adverse effects*
  • Valacyclovir
  • Valine / administration & dosage
  • Valine / analogs & derivatives
  • Valine / therapeutic use
  • Vitreous Body / cytology
  • Vitreous Body / immunology
  • Vitreous Body / virology
  • Whole Genome Sequencing

Substances

  • Antiviral Agents
  • DNA, Viral
  • Herpes Zoster Vaccine
  • Valine
  • Valacyclovir
  • Acyclovir