Response to drugs in schizophrenia: the influence of family history, obstetric complications and ventricular enlargement

Psychol Med. 1988 Aug;18(3):583-92. doi: 10.1017/s0033291700008266.

Abstract

A prospective study of antipsychotic drug treatment showed no difference in response between schizophrenic in-patients with or without a familial predisposition to the illness (N = 53). All patients received at least 600 mg chlorpromazine equivalents antipsychotic medication for 6 weeks. Ventricle brain ratios, ratings of cortical sulcal widening and a history of obstetric complications also failed to account for the variability, but early age of onset was associated with unsatisfactory response.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antipsychotic Agents / therapeutic use*
  • Brain Damage, Chronic / complications*
  • Cerebral Ventricles / pathology*
  • Chlorpromazine / therapeutic use
  • Female
  • Humans
  • Male
  • Neurocognitive Disorders / drug therapy*
  • Neurocognitive Disorders / pathology
  • Prognosis
  • Risk Factors
  • Schizophrenia / drug therapy*
  • Schizophrenia / genetics
  • Schizophrenia / pathology
  • Schizophrenic Psychology*
  • Tomography, X-Ray Computed

Substances

  • Antipsychotic Agents
  • Chlorpromazine