Rivaroxaban and early periprostethic joint infection: our experience

Acta Biomed. 2017 Oct 18;88(4S):38-42. doi: 10.23750/abm.v88i4-S.6792.

Abstract

Background and aim of the work: Periprostethic joint infection (PJI) is a severe post-operative complication after Primary Total Hip Arthroplasty (THA). According to the classification of PJI early acute PJI occurs within 4 weeks from surgery. Some authors think that Rivaroxaban is a risk factor in the incidence of early acute PJI. We analyze our experience about this item.

Materials and methods: We analyze our experience from 1st January 2015 to 31th December 2016. We consider all consecutive hip arthroplasty implants in this period.

Results: In the 205 patients analysed we not find early acute PJI in Rivaroxaban group nor in the others assuming another kind of thromboprophylaxis.

Conclusions: In our series there is no evidence of association between Rivaroxaban and early acute PJI. This is a retrospective cohort study, so we need more studies and more robust experimental designs to confirm these results.

Keywords: acute early periprostethic joint infection, Rivaroxaban, Total Hip Arthroplasty.

MeSH terms

  • Aged
  • Arthroplasty, Replacement, Hip / adverse effects*
  • Arthroplasty, Replacement, Knee / adverse effects
  • Factor Xa Inhibitors / adverse effects*
  • Female
  • Humans
  • Male
  • Prosthesis-Related Infections / etiology*
  • Retrospective Studies
  • Rivaroxaban / adverse effects*

Substances

  • Factor Xa Inhibitors
  • Rivaroxaban