Following the development of a unifying and transparent approach to grading the certainty of evidence and strength or recommendations, the GRADE (Grading of Recommendations Assessment, Development and Evaluation) Working Group has refined its process of moving from Evidence to Decisions. The purpose of its new Evidence to Decision (EtD) frameworks is to help people use evidence in a structured and transparent way to inform decisions in the context of clinical recommendations, coverage decisions, and health system or public health recommendations and decisions. EtD frameworks inform users about the judgments that were made and the evidence supporting those judgments by making the basis for decisions transparent to target audiences. EtD frameworks also facilitate dissemination of recommendations and enable decision makers in other jurisdictions to adopt recommendations or decisions, or adapt them to their context.