Resistance Is Futile: Targeting Mitochondrial Energetics and Metabolism to Overcome Drug Resistance in Cancer Treatment

Cell Metab. 2017 Nov 7;26(5):705-707. doi: 10.1016/j.cmet.2017.10.013.

Abstract

Metabolism is a key regulator of cancer biology; however, its role in therapeutic resistance has remained largely unresolved. Several new studies disclose that mitochondrial metabolism and oxidative phosphorylation at least in part drive chemoresistance in cancer and thus have important implications for targeted and more effective chemotherapies.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use
  • Drug Resistance, Neoplasm / drug effects*
  • Humans
  • Mice
  • Mitochondria / drug effects*
  • Mitochondria / metabolism
  • Neoplasms / drug therapy*
  • Oxidative Phosphorylation / drug effects*
  • Xenograft Model Antitumor Assays

Substances

  • Antineoplastic Agents