The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

Cell Syst. 2018 Jan 24;6(1):13-24. doi: 10.1016/j.cels.2017.11.001. Epub 2017 Nov 29.

Abstract

The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common Fund program that catalogs how human cells globally respond to chemical, genetic, and disease perturbations. Resources generated by LINCS include experimental and computational methods, visualization tools, molecular and imaging data, and signatures. By assembling an integrated picture of the range of responses of human cells exposed to many perturbations, the LINCS program aims to better understand human disease and to advance the development of new therapies. Perturbations under study include drugs, genetic perturbations, tissue micro-environments, antibodies, and disease-causing mutations. Responses to perturbations are measured by transcript profiling, mass spectrometry, cell imaging, and biochemical methods, among other assays. The LINCS program focuses on cellular physiology shared among tissues and cell types relevant to an array of diseases, including cancer, heart disease, and neurodegenerative disorders. This Perspective describes LINCS technologies, datasets, tools, and approaches to data accessibility and reusability.

Keywords: BD2K; L1000; MCF10A; MEMA; P100; data integration; lincsprogram; lincsproject; systems biology; systems pharmacology.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Cataloging / methods*
  • Computational Biology / methods
  • Databases, Chemical / standards
  • Gene Expression Profiling / methods
  • Gene Library
  • Humans
  • Information Storage and Retrieval / methods
  • National Health Programs
  • National Institutes of Health (U.S.) / standards
  • Systems Biology / methods*
  • Transcriptome
  • United States