Differentiation of restrictive cardiomyopathy from pericardial constriction: assessment of diastolic function by radionuclide angiography

J Am Coll Cardiol. 1989 Apr;13(5):1007-14. doi: 10.1016/0735-1097(89)90252-0.

Abstract

Diastolic filling variables were studied in 12 patients with the hemodynamic features of constriction, of whom 5 had restrictive cardiomyopathy, 5 had pericardial constriction and 2 had combined pericardial constriction and restrictive cardiomyopathy. The values were compared with those in 10 normal subjects of comparable age. The filling fractions between 10% and 70% of the diastolic time interval were greater in patients with pericardial constriction than in those with restrictive cardiomyopathy (p less than 0.01 between 20% and 50%, p less than 0.05 at 10%, 60% and 70%), with no overlap. The filling fractions in patients with pericardial constriction were also greater than those in normal subjects between 10% and 60% of the diastolic time interval. The filling fraction was lower in patients with restrictive cardiomyopathy than in normal subjects at 40% of the diastolic time interval (p less than 0.05). The time to peak filling rate in patients with pericardial constriction was shorter (110 +/- 14 ms) than in those with restrictive cardiomyopathy (195 +/- 45 ms, p less than 0.01) or in normal subjects (173 +/- 32 ms, p less than 0.01). The percent of atrial contribution to left ventricular filling was higher in those with restrictive cardiomyopathy (45 +/- 17%) than in those with pericardial constriction (21 +/- 6%, p less than 0.05) or in normal subjects (24 +/- 9%, p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

MeSH terms

  • Adult
  • Aged
  • Angiography
  • Cardiomyopathy, Restrictive / diagnosis*
  • Cardiomyopathy, Restrictive / diagnostic imaging
  • Cardiomyopathy, Restrictive / physiopathology
  • Constriction, Pathologic / diagnosis
  • Constriction, Pathologic / diagnostic imaging
  • Constriction, Pathologic / physiopathology
  • Coronary Vessels / diagnostic imaging*
  • Diagnosis, Differential
  • Diastole
  • Female
  • Heart Diseases / diagnosis
  • Heart Diseases / diagnostic imaging
  • Heart Diseases / physiopathology
  • Humans
  • Male
  • Middle Aged
  • Pericardium*
  • Radionuclide Imaging
  • Systole