Chronic noise-exposure exacerbates insulin resistance and promotes the manifestations of the type 2 diabetes in a high-fat diet mouse model

Lijie Liu; Yi Huang; Cong Fang; Hongyu Zhang; Jing Yang; Chuanying Xuan; Fanfan Wang; Haiying Lu; Shuangfeng Cao; Yongfang Wang; Shengwei Li; Jun Sha; Mingming Zha; Min Guo; Jian Wang

doi:10.1371/journal.pone.0195411

Chronic noise-exposure exacerbates insulin resistance and promotes the manifestations of the type 2 diabetes in a high-fat diet mouse model

PLoS One. 2018 Mar 30;13(3):e0195411. doi: 10.1371/journal.pone.0195411. eCollection 2018.

Authors

Lijie Liu¹, Yi Huang², Cong Fang², Hongyu Zhang², Jing Yang², Chuanying Xuan², Fanfan Wang², Haiying Lu², Shuangfeng Cao², Yongfang Wang¹, Shengwei Li¹, Jun Sha¹, Mingming Zha¹, Min Guo¹, Jian Wang³

Affiliations

¹ Medical College, Southeast University, Nanjing, China.
² Institute of Life Sciences, Southeast University, Nanjing, China.
³ School of Human Communication Disorder, Dalhousie University, Halifax, Nova Scotia, Canada.

Abstract

Epidemiological studies have revealed that noise exposure was associated with an increased risk of type 2 diabetes mellitus (T2DM). However, the exact nature of that association remains to be elucidated. The present study is designed to examine the effects of chronic noise exposure on the development of T2DM in combination with a high-fat-diet (HFD) in mice. Here we show that chronic noise exposure at 85 dB SPL (4 h /day, below the safety limit for occupational noise exposure) exaggerated multiple metabolic abnormalities induced by HFD in C57BL/6J male mice, including worsened glucose intolerance, insulin resistance, fasting hyperglycemia and dyslipidemia. Furthermore, noise exposure exhibited a paradoxical impact on fat accumulation and circulating levels of free fatty acid, indicating a potential stimulating effect of noise on lipolysis. These results provide first in vivo supporting evidence for the causative role of noise exposure in diabetogenesis and pinpoint a noise-associated increase in blood free fatty acid levels as a possible mediator accelerating the effect of noise on the development of insulin resistance and T2DM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blood Glucose / metabolism
Body Composition
Body Weight
Diabetes Mellitus, Type 2 / blood
Diabetes Mellitus, Type 2 / metabolism*
Diet, High-Fat / adverse effects*
Disease Models, Animal
Dyslipidemias / complications
Fasting / blood
Insulin Resistance*
Male
Mice
Mice, Inbred C57BL
Muscle, Skeletal / pathology
Noise / adverse effects*
Signal Transduction
Time Factors

Substances

Blood Glucose

Grants and funding

This work was supported by the National Natural Science Foundation of China (81670935, LJ L, http://www.nsfc.gov.cn) for data collection, analysis and preparation of the manuscript. This work was supported by the National Natural Science Foundation of China (81520108015, GJ T, http://www.nsfc.gov.cn) for data analysis and preparation of the manuscript. This work was supported by the National Natural Science Foundation of China (81100548, LJ L, http://www.nsfc.gov.cn) for data collection and preparation of the manuscript. This work was supported by the National Natural Science Foundation of China (81271086, J W, http://www.nsfc.gov.cn) for data collection. This work was supported by the Fundamental research Fund from Southeast University (2242016K40073, LJ L) for data collection.