Is the Population Detected by Screening in China Truly at High Risk of Stroke?

J Stroke Cerebrovasc Dis. 2018 Aug;27(8):2118-2123. doi: 10.1016/j.jstrokecerebrovasdis.2018.03.009. Epub 2018 Apr 9.

Abstract

Aim: The Chinese Stroke Screening and Prevention Project (CSSPP) considers patients with 3 or more risk factors to be at high risk of stroke, and does not quantitatively assess the risk for stroke. However, to detect high-risk groups more efficiently, a health risk appraisal (HRA) model should be used to assess individual risk of stroke.

Methods: The odds ratios for the 8 risk factors for stroke were pooled and the data were used to develop an HRA model to predict individuals' risks of developing stroke in the next 5 years. The Chinese screening project and HRA screening strategies were then compared.

Results: We assessed 4196 Chinese individuals who received checkups in 2015. The average 5-year risk of stroke was 5.81‰, with men being at higher risk of stroke than women over that period. The average 5-year risk of stroke also increased with the number of risk factors. 932 individuals (22.2%) were identified as being at high risk of stroke according to CSSPP, whereas 318 individuals with fewer than 3 risk factors were considered being at low risk despite having a 5-year risk of stroke greater than 4.0% by our assessment. Notably, among patients with hypertension and diabetes who were classified as being at low risk of stroke by the CSSPP, the HRA recognized 15.9% and 14.3% as being at high risk of stroke, respectively.

Conclusion: All 8 major risk factors affect stroke risk differently, and the efficiency of clustering these risk factors might be improved by considering the relative risk of each factor with an HRA model.

Keywords: Chinese; Stroke; risk assessment; risk factors; screening.

MeSH terms

  • China / epidemiology
  • Cohort Studies
  • Diabetes Mellitus / epidemiology
  • Female
  • Genetic Predisposition to Disease
  • Heart Diseases / epidemiology
  • Humans
  • Hyperlipidemias / epidemiology
  • Hypertension / epidemiology
  • Male
  • Mass Screening*
  • Meta-Analysis as Topic
  • Middle Aged
  • Odds Ratio
  • Overweight / epidemiology
  • Risk Assessment
  • Risk Factors
  • Sedentary Behavior
  • Smoking / epidemiology
  • Stroke / diagnosis*
  • Stroke / epidemiology*
  • Stroke / prevention & control