Human immunodeficiency virus in patients with tuberculous meningitis: systematic review and meta-analysis

Ali Pormohammad; Mohammad Javad Nasiri; Seyed Mohammad Riahi; Fatemeh Fallah

doi:10.1111/tmi.13059

Human immunodeficiency virus in patients with tuberculous meningitis: systematic review and meta-analysis

Trop Med Int Health. 2018 Jun;23(6):589-595. doi: 10.1111/tmi.13059. Epub 2018 May 21.

Authors

Ali Pormohammad¹, Mohammad Javad Nasiri², Seyed Mohammad Riahi³, Fatemeh Fallah²

Affiliations

¹ Student Research Committee, Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
³ Department of Epidemiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

PMID: 29660820
DOI: 10.1111/tmi.13059

Abstract

Introduction: Human immunodeficiency virus (HIV)-infected individuals are at increased risk for all forms of extrapulmonary tuberculosis (TB), including tuberculous meningitis (TBM). This study aimed to investigate the frequency of HIV in patients with TBM.

Methods: PubMed, Embase, Web of Science and Cochrane Library were searched for articles including relevant data. Stata version 14.0 (StataCorp, College Station, Texas, USA) was used to analyse the data.

Results: Twenty studies were identified. The pooled frequency of HIV among adult patients with TBM was 38.0% (95% CI: 21.0-57.0; I² = 97%). In children (under the age of 15 years), 6.0% (95% CI: 1.0-13.0; I² = 0.0%) had HIV infection. In patients with bacterial meningitis other than TBM, 36.0% (95% CI: 19.0-53.0; I² = 100%) were HIV-infected.

Conclusions: A relatively high frequency of HIV in patients with TBM was indicated by our study. Establishment of diagnostic criteria and effective treatment strategies for TBM/HIV co-infection are recommended for better management of patients with TBM+HIV.

Keywords: VIH; human immunodeficiency virus; méningite tuberculeuse; revue systématique; systematic review; tuberculous meningitis.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

MeSH terms

Coinfection
HIV Infections / epidemiology*
Humans
Tuberculosis, Meningeal / epidemiology*
Tuberculosis, Meningeal / therapy