GFI1 is required for RUNX1/ETO positive acute myeloid leukemia

Anna E Marneth; Lacramioara Botezatu; Judith M Hönes; Jimmy C L Israël; Judith Schütte; Lothar Vassen; Robert F Lams; Saskia M Bergevoet; Laura Groothuis; Amit Mandoli; Joost H A Martens; Gerwin Huls; Joop H Jansen; Ulrich Dührsen; Tobias Berg; Tarik Möröy; Christian Wichmann; Mia-Chia Lo; Dong-Er Zhang; Bert A van der Reijden; Cyrus Khandanpour

doi:10.3324/haematol.2017.180844

GFI1 is required for RUNX1/ETO positive acute myeloid leukemia

Haematologica. 2018 Sep;103(9):e395-e399. doi: 10.3324/haematol.2017.180844. Epub 2018 Apr 19.

Authors

Anna E Marneth¹, Lacramioara Botezatu², Judith M Hönes^{2

3}, Jimmy C L Israël¹, Judith Schütte², Lothar Vassen², Robert F Lams², Saskia M Bergevoet¹, Laura Groothuis¹, Amit Mandoli⁴, Joost H A Martens⁴, Gerwin Huls⁵, Joop H Jansen¹, Ulrich Dührsen², Tobias Berg⁶, Tarik Möröy⁷, Christian Wichmann⁸, Mia-Chia Lo⁹, Dong-Er Zhang⁹, Bert A van der Reijden¹⁰, Cyrus Khandanpour^{11

12}

Affiliations

¹ Department of Laboratory Medicine, Laboratory of Hematology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.
² Department of Hematology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Germany.
³ Department of Endocrinology, Diabetes and Metabolism, University Hospital Essen, University Duisburg-Essen, Germany.
⁴ Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, The Netherlands.
⁵ Department of Hematology, University Medical Center Groningen, University of Groningen, The Netherlands.
⁶ Department of Medicine II-Hematology/Oncology, Goethe University, Frankfurt/Main, Germany.
⁷ Institut de recherches cliniques de Montréal (IRCM), Hematopoiesis and Cancer Research Unit, and Université de Montréal, Canada.
⁸ Department of Transfusion Medicine, Cell Therapeutics and Hemostaseology, Ludwig-Maximilian University Hospital, Munich, Germany.
⁹ Department of Pathology & Division of Biological Sciences, University of California San Diego, La Jolla, USA.
¹⁰ Department of Laboratory Medicine, Laboratory of Hematology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands Cyrus.Khandanpour@uk-essen.de Cyrus.Khandanpour@ukmuenster.de Bert.vanderReijden@radboudumc.nl.
¹¹ Department of Hematology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Germany Cyrus.Khandanpour@uk-essen.de Cyrus.Khandanpour@ukmuenster.de Bert.vanderReijden@radboudumc.nl.
¹² Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Münster, Germany.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers, Tumor
Cell Transformation, Neoplastic / genetics
Cell Transformation, Neoplastic / metabolism
DNA-Binding Proteins / genetics*
DNA-Binding Proteins / metabolism
Disease Progression
Gene Expression Regulation, Leukemic
Humans
Leukemia, Myeloid, Acute / genetics*
Leukemia, Myeloid, Acute / metabolism*
Leukemia, Myeloid, Acute / mortality
Leukemia, Myeloid, Acute / pathology
Oncogene Proteins, Fusion / genetics
Oncogene Proteins, Fusion / metabolism
Prognosis
RUNX1 Translocation Partner 1 Protein / genetics*
RUNX1 Translocation Partner 1 Protein / metabolism*
Transcription Factors / genetics*
Transcription Factors / metabolism

Substances

Biomarkers, Tumor
DNA-Binding Proteins
GFI1 protein, human
Oncogene Proteins, Fusion
RUNX1 Translocation Partner 1 Protein
Transcription Factors

Publication types

MeSH terms

Substances

Grants and funding