Add-on therapy with traditional Chinese medicine: An efficacious approach for lipid metabolism disorders

Ying Zhang; Hiroko Kishi; Sei Kobayashi

doi:10.1016/j.phrs.2018.06.004

Add-on therapy with traditional Chinese medicine: An efficacious approach for lipid metabolism disorders

Pharmacol Res. 2018 Aug:134:200-211. doi: 10.1016/j.phrs.2018.06.004. Epub 2018 Jun 21.

Authors

Ying Zhang¹, Hiroko Kishi¹, Sei Kobayashi²

Affiliations

¹ Department of Molecular and Cellular Physiology, Yamaguchi University, Graduate School of Medicine, 1-1-1 Minami-kogushi, Ube, 755-8505, Japan.
² Department of Molecular and Cellular Physiology, Yamaguchi University, Graduate School of Medicine, 1-1-1 Minami-kogushi, Ube, 755-8505, Japan. Electronic address: seikoba@yamaguchi-u.ac.jp.

PMID: 29935947
DOI: 10.1016/j.phrs.2018.06.004

Abstract

Add-on therapy with traditional Chinese medicine (TCM) has been extensively researched in the intractable diseases, such as asthma, cancer, and Alzheimer's disease. As an entirely new concept, add-on therapy of TCM has been also used to prevent and treat hyperlipidemia via lowering cholesterol level. However, the efficacy of add-on therapy with TCM for mediating lipid metabolism disorders remains controversial. In this review, we summarize and provide strong evidence that add-on therapy of TCM as a novel approach is efficacious and safe for hyperlipidemia associated diseases based on the mediation of lipid metabolism disorders.

Keywords: Berberine; Combination therapy; Curcumin; Hyperlipidemia; Lowering-cholesterol.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biomarkers / blood
Drug Therapy, Combination
Drugs, Chinese Herbal / therapeutic use*
Dyslipidemias / blood
Dyslipidemias / diagnosis
Dyslipidemias / drug therapy*
Humans
Hypolipidemic Agents / adverse effects
Hypolipidemic Agents / therapeutic use*
Lipid Metabolism / drug effects*
Lipids / blood*
Risk Factors
Treatment Outcome

Substances

Biomarkers
Drugs, Chinese Herbal
Hypolipidemic Agents
Lipids