The aim of the present study was to analyze the alterations in the, antioxidant enzyme activities (such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and level of glutathione (GSH) and lipid peroxidation (LPO) of wheat acutely treated with CP and DM treatments at low, high doses and their combination. CP and DM were administered to wheat in different doses of 1, 1.5, 5 and 35 mg kg-1 given alone and combination. After 3 weeks, antioxidant enzyme activities, and the level of GSH and LPO were recorded and analyzed. Antioxidative defense mechanisms and LPO in wheat display different responses depending on different pesticide treatments and doses. Biochemical analysis showed that exposure of the CP and DM cause plant tissue damage. It is suggested that appropriate ecotoxicological risk assessment should be made in the areas where DM is proposed to be used in pest control when compared to CP. In the present study, we also concluded that the effect of the combined of CP and DM on the oxidative stress may be synergistic.