The structural gene for aldolase B (ALDB) maps to 9q13----32

Ann Hum Genet. 1985 Jul;49(3):173-80. doi: 10.1111/j.1469-1809.1985.tb01691.x.

Abstract

We used a cloned cDNA probe for the B subunit of human aldolase (ALDB) and Southern blotting techniques to analyse DNA from a series of rodent X human somatic cell hybrids for the presence of specific ALDB-related sequences. Our results provide evidence for the assignment of the gene for ALDB to chromosome 9. Moreover, by direct gene dosage determination in two patients with chromosome 9 unbalanced rearrangements and by in situ hybridization we refined the regional chromosomal assignment to 9q13----q32 and most probably to 9q21.3----9q22.2.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromosome Banding
  • Chromosome Mapping*
  • Chromosomes, Human, 6-12 and X*
  • Cricetinae
  • Cricetulus
  • DNA / genetics
  • DNA Restriction Enzymes
  • Electrophoresis, Agar Gel
  • Female
  • Fructose-Bisphosphate Aldolase / genetics*
  • Genes*
  • Genetic Markers
  • Humans
  • Hybrid Cells
  • Infant
  • Male
  • Nucleic Acid Hybridization

Substances

  • Genetic Markers
  • DNA
  • DNA Restriction Enzymes
  • Fructose-Bisphosphate Aldolase