The FDA recognized the combination of acetylsalicylic acid (250 mg), acetaminophen (250 mg), and caffeine (65 mg) as safe and effective in treating acute headaches, especially migraine, and was also considered effective by the American Headache Society. This combination is well-tolerated in episodic tension-type headaches and considered superior to acetaminophen; all components in this combination medication are considered safe during breastfeeding and can be taken orally for acute migraine attacks. The mechanism of action of this combination is from the accumulation of the components' effects; each component has a different mechanism of action. This activity reviews the indications, contraindications, activity, adverse events, and other key elements of acetaminophen/aspirin/caffeine therapy in the clinical setting as it relates to the essential points needed by members of an interprofessional team managing the care of patients with migraine headaches and its related conditions and sequelae.
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